Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. ... A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.
Mesh Terms:
Cell Cycle Proteins, Genomic Instability, Molecular Chaperones, Mutation, Phosphotransferases, Saccharomyces cerevisiae Proteins
Cell Cycle Proteins, Genomic Instability, Molecular Chaperones, Mutation, Phosphotransferases, Saccharomyces cerevisiae Proteins
Cell Cycle
Date: Dec. 15, 2007
PubMed ID: 18075309
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