Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.
A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we ... show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
Mesh Terms:
Acetylation, Animals, Cell Line, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Genome, Heat-Shock Response, Histone Deacetylase 1, Histone Deacetylase 2, Histones, Humans, Mice, RNA, Small Interfering, Transcription Factors
Acetylation, Animals, Cell Line, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Genome, Heat-Shock Response, Histone Deacetylase 1, Histone Deacetylase 2, Histones, Humans, Mice, RNA, Small Interfering, Transcription Factors
Mol. Biol. Cell
Date: Dec. 01, 2009
PubMed ID: 19793920
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