I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a ... novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Antigens, CD, Bacterial Proteins, Binding Sites, Carrier Proteins, Cloning, Molecular, Humans, Macromolecular Substances, Mice, Molecular Sequence Data, NF-kappa B, Peptides, Protein Binding, Proteins, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II, Signal Transduction, TNF Receptor-Associated Factor 2, X-Linked Inhibitor of Apoptosis Protein
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Antigens, CD, Bacterial Proteins, Binding Sites, Carrier Proteins, Cloning, Molecular, Humans, Macromolecular Substances, Mice, Molecular Sequence Data, NF-kappa B, Peptides, Protein Binding, Proteins, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II, Signal Transduction, TNF Receptor-Associated Factor 2, X-Linked Inhibitor of Apoptosis Protein
Proc. Natl. Acad. Sci. U.S.A.
Date: Aug. 06, 1996
PubMed ID: 8710854
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