Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.
The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same ... pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein that controls chromatin structure. Hence, a direct consequence of LIN-12 or GLP-1 activation may be an alteration of chromatin structure that produces changes in transcriptional activity.
Mesh Terms:
Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Lineage, Chromatin, Gene Expression Regulation, Developmental, Genes, Helminth, Helminth Proteins, Meiosis, Membrane Proteins, Mitosis, Mutation, Receptors, Notch, Signal Transduction, Temperature, Transcription Factors
Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Lineage, Chromatin, Gene Expression Regulation, Developmental, Genes, Helminth, Helminth Proteins, Meiosis, Membrane Proteins, Mitosis, Mutation, Receptors, Notch, Signal Transduction, Temperature, Transcription Factors
Science
Date: Jul. 05, 1996
PubMed ID: 8658178
View in: Pubmed Google Scholar
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