FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
We identified and cloned a novel human protein that contains FADD/Mort1 death effector domain homology regions, designated FLAME-1. FLAME-1, although most similar in structure to Mch4 and Mch5, does not possess caspase activity but can interact specifically with FADD, Mch4, and Mch5. Interestingly, FLAME-1 is recruited to the Fas receptor ... complex and can abrogate Fas/TNFR-induced apoptosis upon expression in FasL/tumor necrosis factor-sensitive MCF-7 cells, possibly by acting as a dominant-negative inhibitor. These findings identify a novel endogenous control point that regulates Fas/TNFR1-mediated apoptosis.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Carrier Proteins, Caspase 10, Caspase 8, Caspase 9, Caspases, Cloning, Molecular, Cysteine Endopeptidases, Fas Ligand Protein, Fas-Associated Death Domain Protein, Humans, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins, Molecular Sequence Data, Proteins, Sequence Homology, Amino Acid, TNF Receptor-Associated Factor 1, Tissue Distribution, Ultraviolet Rays
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Carrier Proteins, Caspase 10, Caspase 8, Caspase 9, Caspases, Cloning, Molecular, Cysteine Endopeptidases, Fas Ligand Protein, Fas-Associated Death Domain Protein, Humans, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins, Molecular Sequence Data, Proteins, Sequence Homology, Amino Acid, TNF Receptor-Associated Factor 1, Tissue Distribution, Ultraviolet Rays
J. Biol. Chem.
Date: Jul. 25, 1997
PubMed ID: 9228018
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