Homo sapiens
NKX2-5
CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3
NK2 homeobox 5
GO Process (37)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IMP]
- atrial cardiac muscle cell development [ISS]
- atrial septum morphogenesis [IMP]
- cardiac conduction system development [IMP]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle tissue morphogenesis [IMP]
- cell differentiation [ISS]
- embryonic heart tube development [ISS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- hemopoiesis [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- outflow tract septum morphogenesis [IMP]
- pharyngeal system development [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of heart contraction [ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of sodium ion transport [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISS]
- positive regulation of transcription initiation from RNA polymerase II promoter [ISS]
- positive regulation of transcription via serum response element binding [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of voltage-gated calcium channel activity [ISS]
- regulation of cardiac muscle contraction [ISS]
- right ventricular cardiac muscle tissue morphogenesis [IMP]
- septum secundum development [IMP]
- spleen development [IMP, ISS]
- thyroid gland development [IMP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- serum response element binding [ISS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
107864
9606
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- Interactors 71
- Interactions 90
- Network