Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).

Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription. The provision of NIP45 together with NFAT and the T helper cell type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, such as ...
B cells or Th1 clones, results in substantial IL-4 secretion to levels that approximate those produced by primary Th2 cells. In studies designed to further our understanding of NIP45 activity, we have uncovered a novel facet of IL-4 gene regulation. We present evidence that members of the tumor necrosis factor receptor-associated factor (TRAF) family of proteins, generally known to function as adapter proteins that transduce signals from the tumor necrosis factor receptor superfamily, contribute to the repression of IL-4 gene transcription and that this effect is mediated through their interaction with NIP45.
Mesh Terms:
Animals, CD4-Positive T-Lymphocytes, Carrier Proteins, Interleukin-4, Intracellular Signaling Peptides and Proteins, Mice, Mice, Transgenic, Nuclear Proteins, Promoter Regions, Genetic, Proteins, Receptors, Tumor Necrosis Factor, T-Lymphocytes, Helper-Inducer, TNF Receptor-Associated Factor 2, Th2 Cells, Transcription, Genetic
J. Exp. Med.
Date: Jul. 02, 2001
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