Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized ... beta-catenin. Fragments of APC that contained a conductin-binding domain also blocked beta-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.
Mesh Terms:
Adenomatous Polyposis Coli Protein, Amino Acid Sequence, Animals, Binding Sites, Body Patterning, Calcium-Calmodulin-Dependent Protein Kinases, Cytoskeletal Proteins, Glycogen Synthase Kinase 3, Humans, Mice, Molecular Sequence Data, Mutation, Phosphorylation, Proteins, Proto-Oncogene Proteins, Repressor Proteins, Signal Transduction, Trans-Activators, Tumor Cells, Cultured, Xenopus, Xenopus Proteins, beta Catenin
Adenomatous Polyposis Coli Protein, Amino Acid Sequence, Animals, Binding Sites, Body Patterning, Calcium-Calmodulin-Dependent Protein Kinases, Cytoskeletal Proteins, Glycogen Synthase Kinase 3, Humans, Mice, Molecular Sequence Data, Mutation, Phosphorylation, Proteins, Proto-Oncogene Proteins, Repressor Proteins, Signal Transduction, Trans-Activators, Tumor Cells, Cultured, Xenopus, Xenopus Proteins, beta Catenin
Science
Date: Apr. 24, 1998
PubMed ID: 9554852
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