Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.
Through a genome-wide cDNA microarray, we identified that the paternally expressed gene 10 (PEG10) was highly expressed in a great majority of hepatocellular carcinomas, although its expression was absent in normal liver cells. Exogenous expression of PEG10 conferred oncogenic activity and transfection of hepatoma cells with antisense S-oligonucleotides suppressing PEG10 ... resulted in their growth inhibition. Additional experiments revealed that PEG10 protein associated with SIAH1, a mediator of apoptosis, and that overexpression of PEG10 decreased the cell death mediated by SIAH1. These findings suggested that development of drug(s) inhibiting PEG10 activity could be a novel approach for the treatment of hepatocellular carcinomas.
Mesh Terms:
Apoptosis, Carcinoma, Hepatocellular, Cell Division, Cell Line, Cell Transformation, Neoplastic, Gene Expression Regulation, Neoplastic, Humans, Kidney, Liver Neoplasms, Neoplasm Proteins, Nuclear Proteins, Oligodeoxyribonucleotides, Antisense, Protein Interaction Mapping, Proteins, Recombinant Fusion Proteins, Transfection, Tumor Cells, Cultured, Tumor Stem Cell Assay, Ubiquitin-Protein Ligases
Apoptosis, Carcinoma, Hepatocellular, Cell Division, Cell Line, Cell Transformation, Neoplastic, Gene Expression Regulation, Neoplastic, Humans, Kidney, Liver Neoplasms, Neoplasm Proteins, Nuclear Proteins, Oligodeoxyribonucleotides, Antisense, Protein Interaction Mapping, Proteins, Recombinant Fusion Proteins, Transfection, Tumor Cells, Cultured, Tumor Stem Cell Assay, Ubiquitin-Protein Ligases
Cancer Res.
Date: Jun. 15, 2003
PubMed ID: 12810624
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