Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.

LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LXXLL motif. LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Repression by ...
LCoR is abolished by histone deacetylase inhibitor trichostatin A in a receptor-dependent fashion, indicating HDAC-dependent and -independent modes of action. LCoR binds directly to specific HDACs in vitro and in vivo. Moreover, LCoR functions by recruiting C-terminal binding protein corepressors through two consensus binding motifs and colocalizes with CtBPs in the nucleus. LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms.
Mesh Terms:
Adult, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, COS Cells, Enzyme Inhibitors, Estrogen Receptor alpha, Fetus, Genes, Reporter, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, In Situ Hybridization, Ligands, Molecular Sequence Data, Nuclear Proteins, Nuclear Receptor Coactivator 2, Placenta, Protein Binding, Receptors, Estrogen, Recombinant Fusion Proteins, Repressor Proteins, Sequence Alignment, Transcription Factors, Transcriptional Activation, Tumor Cells, Cultured, Two-Hybrid System Techniques
Mol. Cell
Date: Jan. 01, 2003
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