ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

ALL-1 is a member of the human trithorax/Polycomb gene family and is also involved in acute leukemia. ALL-1 is present within a stable, very large multiprotein supercomplex composed of > or =29 proteins. The majority of the latter are components of the human transcription complexes TFIID (including TBP), SWI/SNF, NuRD, ...
hSNF2H, and Sin3A. Other components are involved in RNA processing or in histone methylation. The complex remodels, acetylates, deacetylates, and methylates nucleosomes and/or free histones. The complex's H3-K4 methylation activity is conferred by the ALL-1 SET domain. Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL-1-dependent Hox a9 gene. In parallel, H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter.
Mesh Terms:
Blotting, Western, Cell Nucleus, Chromatin, DNA-Binding Proteins, Hela Cells, Histone-Lysine N-Methyltransferase, Histones, Homeodomain Proteins, Humans, K562 Cells, Mass Spectrometry, Methylation, Methyltransferases, Myeloid-Lymphoid Leukemia Protein, Precipitin Tests, Protein Binding, Protein Methyltransferases, Protein Processing, Post-Translational, Protein Structure, Tertiary, Proto-Oncogenes, Silver Staining, Transcription Factors, Transcription, Genetic
Mol. Cell
Date: Nov. 01, 2002
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