ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.

Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel intermediate in these signaling pathways that bridges TRAF6 to MEKK-1. This adapter protein, which we have named ECSIT (evolutionarily ...
conserved signaling intermediate in Toll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-kappaB. These results indicate an important role for ECSIT in signaling to NF-kappaB and suggest that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Cell Line, Transformed, Cloning, Molecular, Drosophila, Drosophila Proteins, Enzyme Activation, Evolution, Humans, Insect Proteins, MAP Kinase Kinase Kinase 1, Membrane Glycoproteins, Mice, Molecular Sequence Data, NF-kappa B, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases, Proteins, Receptors, Cell Surface, Receptors, Immunologic, Receptors, Interleukin-1, Saccharomyces cerevisiae, Signal Transduction, TNF Receptor-Associated Factor 6, Toll-Like Receptors
Genes Dev.
Date: Aug. 15, 1999
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