TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negative mutant TAB2 impairs their activation ... by IL-1. IL-1 stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Biological Transport, Carrier Proteins, Cell Membrane, Cloning, Molecular, Cytosol, Enzyme Activation, Gene Library, Humans, Interleukin-1, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinases, Models, Biological, Molecular Sequence Data, NF-kappa B, Protein Binding, Proteins, Signal Transduction, TNF Receptor-Associated Factor 6, Two-Hybrid System Techniques
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Biological Transport, Carrier Proteins, Cell Membrane, Cloning, Molecular, Cytosol, Enzyme Activation, Gene Library, Humans, Interleukin-1, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinases, Models, Biological, Molecular Sequence Data, NF-kappa B, Protein Binding, Proteins, Signal Transduction, TNF Receptor-Associated Factor 6, Two-Hybrid System Techniques
Mol. Cell
Date: Apr. 01, 2000
PubMed ID: 10882101
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