Homo sapiens
PDGFB
IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, LL22NC03-10C3.2
platelet-derived growth factor beta polypeptide
GO Process (60)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to mycophenolic acid [ISS]
- embryonic placenta development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- hemopoiesis [IMP]
- innate immune response [TAS]
- metanephric glomerular mesangial cell development [ISS]
- monocyte chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- paracrine signaling [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive chemotaxis [IDA]
- positive regulation of DNA biosynthetic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of glomerular mesangial cell proliferation [IDA]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of metanephric mesenchymal cell migration [IDA]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- reactive oxygen species metabolic process [IMP]
- response to wounding [IDA, NAS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 93
- Interactions 148
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