Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and ... present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.
Mesh Terms:
Actins, Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, COS Cells, Carrier Proteins, Cloning, Molecular, Dynamin I, Dynamins, GTP Phosphohydrolases, Nerve Tissue Proteins, Precipitin Tests, Protein Binding, Protein Isoforms, Synapses, Two-Hybrid System Techniques
Actins, Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, COS Cells, Carrier Proteins, Cloning, Molecular, Dynamin I, Dynamins, GTP Phosphohydrolases, Nerve Tissue Proteins, Precipitin Tests, Protein Binding, Protein Isoforms, Synapses, Two-Hybrid System Techniques
J. Biol. Chem.
Date: Dec. 21, 2001
PubMed ID: 11583995
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