Homo sapiens
CCL5
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
chemokine (C-C motif) ligand 5
GO Process (62)
GO Function (14)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IMP]
- activation of phospholipase D activity [IDA]
- calcium ion transport [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular protein complex assembly [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IDA, TAS]
- chemotaxis [NAS]
- dendritic cell chemotaxis [TAS]
- eosinophil chemotaxis [IDA]
- exocytosis [IDA]
- inflammatory response [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [TAS]
- monocyte chemotaxis [IC]
- negative regulation by host of viral transcription [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of T cell apoptotic process [IDA]
- negative regulation of chemokine-mediated signaling pathway [IDA]
- negative regulation of viral genome replication [IDA]
- neutrophil activation [IDA]
- positive chemotaxis [IDA]
- positive regulation of JAK-STAT cascade [TAS]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-cell adhesion mediated by integrin [IDA]
- positive regulation of cellular biosynthetic process [IDA]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of innate immune response [TAS]
- positive regulation of macrophage chemotaxis [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of translational initiation [NAS]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
- positive regulation of viral genome replication [TAS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of T cell activation [IDA]
- regulation of chronic inflammatory response [TAS]
- regulation of insulin secretion [IDA]
- regulation of neuron death [IDA]
- response to toxic substance [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 64
- Interactions 82
- Chemical Interactions 4
- Network
- PTM Sites 1