Homo sapiens
ADAM17
ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
ADAM metallopeptidase domain 17
GO Process (41)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- B cell differentiation [ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- Notch receptor processing [IDA]
- PMA-inducible membrane protein ectodomain proteolysis [IDA, IMP]
- T cell differentiation in thymus [ISS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cell adhesion [IDA]
- cell adhesion mediated by integrin [IDA]
- cell motility [ISS]
- collagen catabolic process [TAS]
- epidermal growth factor receptor signaling pathway [IDA, TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- germinal center formation [ISS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of interleukin-8 production [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil mediated immunity [IC]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [ISS]
- positive regulation of chemokine production [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IDA, IMP]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- proteolysis [IDA]
- regulation of mast cell apoptotic process [ISS]
- response to drug [ISS]
- response to high density lipoprotein particle [IDA]
- response to hypoxia [IDA]
- response to lipopolysaccharide [IDA]
- spleen development [ISS]
- wound healing, spreading of epidermal cells [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
112731
9606
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- Interactors 88
- Interactions 111
- Chemical Interactions 8
- Network
- PTM Sites 62