Homo sapiens

TOP1

TOPI, RP3-511B24.1

topoisomerase (DNA) I

GO Process (9)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

DNA replication [IBA]

DNA topological change [IBA, IDA]

chromatin remodeling [IBA, IMP]

chromosome segregation [IBA]

circadian regulation of gene expression [IMP]

circadian rhythm [IEP]

phosphorylation [NAS]

programmed cell death [NAS]

response to drug [IEP]

Gene Ontology Molecular Function

DNA binding [IDA]
DNA topoisomerase type I activity [IDA, IMP]
chromatin binding [IDA]
core promoter sequence-specific DNA binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasmic mRNA processing body [IDA]

nuclear chromosome [IDA]

nucleolus [IDA]

nucleoplasm [IDA]

nucleus [IDA]

replication fork protection complex [IBA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Download Curated Data for this Protein

113003

9606

Interactor Statistics

Proteins/Genes

686

Chemicals

Publications

270

Interactors w/ Physical (HTP) Evidence (532)
Interactors w/ Physical (LTP) Evidence (79)
Interactors w/ Genetic (HTP) Evidence (23)
Interactors w/ More than One Evidence Type (52)
Chemical Interactors (8)

Interactors 694
Interactions 878
Chemical Interactions 30
Network
PTM Sites 47

Result Summary

TOP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]
DNA topoisomerase type I activity [IDA, IMP]
chromatin binding [IDA]
core promoter sequence-specific DNA binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

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Result Summary

TOP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]DNA topoisomerase type I activity [IDA, IMP]chromatin binding [IDA]core promoter sequence-specific DNA binding [IDA]poly(A) RNA binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Advanced Filters

Global Filter

Column Specific Filters

DNA binding [IDA]
DNA topoisomerase type I activity [IDA, IMP]
chromatin binding [IDA]
core promoter sequence-specific DNA binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]