Homo sapiens
TP73
P73
tumor protein p73
GO Process (17)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, IDA]
- mismatch repair [TAS]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of JUN kinase activity [IBA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IMP]
- regulation of mitotic cell cycle [IMP]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [IPI]
- p53 binding [IBA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [IPI]
- p53 binding [IBA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
113014
9606
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- Interactors 159
- Interactions 366
- Network
- PTM Sites 49