IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.
A novel member of the interleukin-1 receptor family has been cloned by polymerase chain reaction using degenerate oligonucleotide primers derived from regions of sequence conservation, using as template a yeast artificial chromosome known to contain both interleukin-1 (IL-1) receptors and T1/ST2. The new receptor, called IL-1 receptor-related protein or IL-1Rrp, ... fails to bind any of the known IL-1 ligands. A chimeric receptor, in which the IL-1Rrp cytoplasmic domain is fused to the extracellular and transmembrane regions of the IL-1 receptor, responds to IL-1 following transfection into COS cells by activation of NFkappaB and induction of IL-8 promoter function.
Mesh Terms:
Amino Acid Sequence, Animals, Cell Line, Cell Membrane, Cercopithecus aethiops, Cloning, Molecular, Cytoplasm, DNA Primers, Humans, Interleukin-18 Receptor alpha Subunit, Interleukin-8, Mice, Molecular Sequence Data, NF-kappa B, Polymerase Chain Reaction, Promoter Regions, Genetic, Protein Biosynthesis, Proteins, Receptors, Interleukin-1, Receptors, Interleukin-18, Recombinant Fusion Proteins, Sequence Homology, Amino Acid, Transfection
Amino Acid Sequence, Animals, Cell Line, Cell Membrane, Cercopithecus aethiops, Cloning, Molecular, Cytoplasm, DNA Primers, Humans, Interleukin-18 Receptor alpha Subunit, Interleukin-8, Mice, Molecular Sequence Data, NF-kappa B, Polymerase Chain Reaction, Promoter Regions, Genetic, Protein Biosynthesis, Proteins, Receptors, Interleukin-1, Receptors, Interleukin-18, Recombinant Fusion Proteins, Sequence Homology, Amino Acid, Transfection
J. Biol. Chem.
Date: Feb. 23, 1996
PubMed ID: 8626725
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