Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving ...
repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively.
Mesh Terms:
Binding Sites, CDC2-CDC28 Kinases, Carrier Proteins, Cell Cycle, Cell Division, Cyclin A, Cyclin D, Cyclin E, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinases, Cyclins, DNA Helicases, Enzyme Inhibitors, G1 Phase, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Nuclear Proteins, Phosphorylation, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Repressor Proteins, Retinoblastoma Protein, S Phase, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured
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Date: Mar. 31, 2000
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