Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix.

Import of proteins into the matrix is driven by the Tim23 presequence translocase-associated import motor PAM. The core component of PAM is the mitochondrial chaperone mtHsp70, which ensures efficient translocation of proteins across the inner membrane through interactions with the J-protein complex Pam16-Pam18 (Tim16-Tim14) and its cochaperone Tim44. The recently ...
identified non-essential Pam17 is a further member of PAM. Genetic and biochemical analyses reveal synthetic interactions between PAM17 and TIM44. Pam17 is involved in an early stage of protein translocation whereas Tim44 assists in a later step of transport, suggesting that both proteins can cooperate in a complementary manner in protein import.
Mesh Terms:
Calcium-Transporting ATPases, Membrane Proteins, Mitochondria, Mitochondrial Membrane Transport Proteins, Molecular Chaperones, Phenotype, Protein Biosynthesis, Protein Precursors, Protein Transport, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Int. J. Biochem. Cell Biol.
Date: Nov. 01, 2009
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