Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.

The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression ...
by Mad and thyroid hormone receptor (TRbeta). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRbeta. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis.
Mesh Terms:
Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, DNA-Binding Proteins, Embryo, Mammalian, Fluorescent Antibody Technique, Gene Expression Regulation, Histone Deacetylases, In Situ Hybridization, Mice, Mice, Knockout, Mutation, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Ornithine Decarboxylase, Protein Binding, Proto-Oncogene Proteins, Receptors, Thyroid Hormone, Repressor Proteins, Transcription, Genetic
Genes Dev.
Date: Feb. 15, 1999
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