Homo sapiens

HIST1H4L

H4.k, H4/k, H4FK

histone cluster 1, H4l

GO Process (9)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

CENP-A containing nucleosome assembly [TAS]

DNA replication-dependent nucleosome assembly [IDA]

DNA replication-independent nucleosome assembly [IDA]

chromatin organization [TAS]

histone H4-K20 demethylation [TAS]

mitotic cell cycle [TAS]

negative regulation of megakaryocyte differentiation [IDA]

nucleosome assembly [TAS]

telomere maintenance [TAS]

Gene Ontology Molecular Function

DNA binding [TAS]
histone demethylase activity (H4-K20 specific) [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [TAS]

extracellular vesicular exosome [IDA]

membrane [IDA]

nuclear chromosome [IDA]

nucleoplasm [TAS]

nucleosome [TAS]

nucleus [IDA]

protein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Download Curated Data for this Protein

113964

9606

PTM statistics

Proteins

PTM Sites

Publications

Sumoylation Sites (1)
Phosphorylation Sites (1)
Ubiquitination Sites (7)

Interactors 64
Interactions 91
Network
PTM Sites 9

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 9 total post translational modifications

Sort By: [Default] [Alphabetical] [PTM count] [Length] [Status]

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NP_003537

histone H4

Length: 103

1
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
51
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG
101
FGG

Location	PTM	Residue	Source(s)	Note(s)
13	Ubiquitination	K	Akimov V (2018)	-
			Pedersen AK (2021)	-
			Rose CM (2016)	-
			Stes E (2014)	-
32	Ubiquitination	K	Abreha MH (2018)	-
			Akimov V (2018)	-
			Beltrao P (2012)	-
			Danielsen JM (2011)	-
			Emanuele MJ (2011)	-
			Lee KA (2011)	-
			Li W (2018)	-
			Matsumoto M (2005)	-
			Ordureau A (2020)	-
			Pedersen AK (2021)	-
			Povlsen LK (2012)	-
			Renaudin X (2014)	-
			Rose CM (2016)	-
			Sarraf SA (2013)	-
			Shi Y (2011)	-
			Stes E (2014)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Vogl AM (2020)	-
			Wagner SA (2011)	-
			Xu G (2010)	-
			Zhang H (2021) [show 17 more ]	-
48	Phosphorylation	S	Bouhaddou M (2020)	-
48	Phosphorylation	S	Ordureau A (2020)	-
60	Ubiquitination	K	Akimov V (2018)	-
			Beltrao P (2012)	-
			Danielsen JM (2011)	-
			Emanuele MJ (2011)	-
			Lee KA (2011)	-
			Povlsen LK (2012)	-
			Sarraf SA (2013)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Wagner SA (2011)	-
			Xu G (2010)	-
			Zhang H (2021) [show 7 more ]	-
78	Ubiquitination	K	Abreha MH (2018)	-
			Akimov V (2018)	-
			Beltrao P (2012)	-
			Danielsen JM (2011)	-
			Emanuele MJ (2011)	-
			Li W (2018)	-
			Pedersen AK (2021)	-
			Povlsen LK (2012)	-
			Sarraf SA (2013)	-
			Stes E (2014)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Wagner SA (2011)	-
			Zhang H (2021) [show 9 more ]	-
80	Ubiquitination	K	Akimov V (2018)	-
			Beltrao P (2012)	-
			Danielsen JM (2011)	-
			Matsumoto M (2005)	-
			Povlsen LK (2012)	-
			Sarraf SA (2013)	-
			Stukalov A (2021)	-
			Wagner SA (2011)	-
			Zhang H (2021) [show 4 more ]	-
92	Ubiquitination	K	Akimov V (2018)	-
			Beltrao P (2012)	-
			Emanuele MJ (2011)	-
			Matsumoto M (2005)	-
			Pedersen AK (2021)	-
			Povlsen LK (2012)	-
			Sarraf SA (2013)	-
			Stes E (2014)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Vogl AM (2020)	-
			Wagner SA (2011)	-
			Xu G (2010)	-
			Zhang H (2021) [show 9 more ]	-

View

Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Sumoylation	K	Grant MM (2010)	eyJOT1RFUyI6WyJsaWtlbHkgU3VtbyBjb25qdWdhdGUiXSwiUkVMQVRJT05TSElQUyI6eyJTVU1PMSI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTg4XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3N1bW8xLmh0bWwnIGFsdD0nU1VNTzEnPlNVTU8xPFwvYT48XC9zcGFuPiIsIlNVTU8yIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTI0OTdcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvc3VtbzIuaHRtbCcgYWx0PSdTVU1PMic+U1VNTzI8XC9hPjxcL3NwYW4+In19
-	Sumoylation	K	Tatham MH (2011)	eyJSRUxBVElPTlNISVBTIjp7IlNVTU8xIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxODhcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvc3VtbzEuaHRtbCcgYWx0PSdTVU1PMSc+U1VNTzE8XC9hPjxcL3NwYW4+IiwiU1VNTzIiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzExMjQ5N1wvc3VtbWFyeVwvaG9tby1zYXBpZW5zXC9zdW1vMi5odG1sJyBhbHQ9J1NVTU8yJz5TVU1PMjxcL2E+PFwvc3Bhbj4ifX0=
-	Ubiquitination	K	Altun M (2011)	eyJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiJ9fQ==
			Renaudin X (2014)	eyJOT1RFUyI6WyJUYWJsZSBTMjsgUHJvdGVpbnMgYW5kIHBlcHRpZGVzIGlkZW50aWZpZWQgaW4gRkFOQ0EgYW5kIEZBTkNBLWNvcnJlY3RlZCBjZWxsIGxpbmVzIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Stes E (2014)	eyJOT1RFUyI6WyJpbnRlcmFjdGlvbiBkZXRlY3RlZCBieSBDT0ZSQURJQyIsImxpa2VseSB1YmlxdWl0aW4gY29uanVnYXRlIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Udeshi ND (2012)	eyJOT1RFUyI6WyJCeSBNUyBkZXRlY3Rpb24gb2YgYSBseXNpbmUgZGktZ2x5Y2luZSByZW1uYW50Il0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
SUMO1	Conjugate	-	Sumoylation	K	PTM	Grant MM (2010)
SUMO2	Conjugate	-	Sumoylation	K	PTM	Tatham MH (2011)
UBC	Conjugate	-	Ubiquitination	K	PTM	Altun M (2011)
						Renaudin X (2014)
						Stes E (2014)
						Udeshi ND (2012)

Result Summary