Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators.

Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). ...
Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.
Mesh Terms:
Animals, Bone Morphogenetic Protein Receptors, Bone Morphogenetic Proteins, COS Cells, Calcitriol, Cell Nucleus, DNA-Binding Proteins, Histone Acetyltransferases, Ligands, Nuclear Receptor Coactivator 1, Phosphorylation, Receptor Cross-Talk, Receptors, Calcitriol, Receptors, Cell Surface, Receptors, Growth Factor, Receptors, Retinoic Acid, Receptors, Transforming Growth Factor beta, Recombinant Fusion Proteins, Retinoid X Receptors, Signal Transduction, Smad3 Protein, Trans-Activators, Transcription Factors, Transcriptional Activation, Transfection, Transforming Growth Factor beta
Date: Feb. 26, 1999
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