Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties. Retinoic acid ... receptor, CREB, and STAT-1 also require different histone acetyltransferase (HAT) activities to activate transcription. Thus, transcription factor-specific differences in configuration and content of the coactivator complex dictate requirements for specific acetyltransferase activities, providing an explanation, at least in part, for the presence of multiple HAT components of the complex.
Mesh Terms:
Acetyltransferases, CREB-Binding Protein, Cell Cycle Proteins, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, DNA-Binding Proteins, Gene Expression Regulation, Hela Cells, Histone Acetyltransferases, Humans, Ligands, Mutation, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Coactivator 1, Nuclear Receptor Coactivator 3, Promoter Regions, Genetic, Receptors, Retinoic Acid, Repressor Proteins, STAT1 Transcription Factor, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Transcriptional Activation, p300-CBP Transcription Factors
Acetyltransferases, CREB-Binding Protein, Cell Cycle Proteins, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, DNA-Binding Proteins, Gene Expression Regulation, Hela Cells, Histone Acetyltransferases, Humans, Ligands, Mutation, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Coactivator 1, Nuclear Receptor Coactivator 3, Promoter Regions, Genetic, Receptors, Retinoic Acid, Repressor Proteins, STAT1 Transcription Factor, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Transcriptional Activation, p300-CBP Transcription Factors
Science
Date: Jan. 30, 1998
PubMed ID: 9445475
View in: Pubmed Google Scholar
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