LEF-1 activates the transcription of E2F1.
LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further beta-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that ... LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.
Mesh Terms:
Animals, COS Cells, Cells, Cultured, Cercopithecus aethiops, E2F1 Transcription Factor, Histone Deacetylases, Humans, Lymphoid Enhancer-Binding Factor 1, Transcriptional Activation
Animals, COS Cells, Cells, Cultured, Cercopithecus aethiops, E2F1 Transcription Factor, Histone Deacetylases, Humans, Lymphoid Enhancer-Binding Factor 1, Transcriptional Activation
Biochem. Biophys. Res. Commun.
Date: Jan. 04, 2008
PubMed ID: 17980157
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