Metastasis-associated protein 1 inhibits p53-induced apoptosis.
Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of cancer cells. MTA1 was associated with p53 ... in a co-immunoprecipitation assay. MTA1 also had deacetylation activity on p53 in human non-small cell lung cancer cells H1299 and human hepatoma cells SK-Hep1. MTA1 attenuated the transactivation and p21 induction by p53. Moreover, MTA1 expression decreased p53-mediated apoptosis. These results indicate that MTA1 inhibits p53-induced apoptosis by deacetylation of p53, which might be related to the increased metastatic potential of cancer cells with high MTA1 expression.
Mesh Terms:
Acetylation, Apoptosis, Blotting, Western, Carcinoma, Hepatocellular, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Neoplastic, Histone Deacetylases, Humans, Immunoprecipitation, Kidney, Liver Neoplasms, Luciferases, Lung Neoplasms, Repressor Proteins, Transcription, Genetic, Tumor Suppressor Protein p53
Acetylation, Apoptosis, Blotting, Western, Carcinoma, Hepatocellular, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Neoplastic, Histone Deacetylases, Humans, Immunoprecipitation, Kidney, Liver Neoplasms, Luciferases, Lung Neoplasms, Repressor Proteins, Transcription, Genetic, Tumor Suppressor Protein p53
Oncol. Rep.
Date: Nov. 01, 2007
PubMed ID: 17914590
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