The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.

In the developing brain, the organization of the neuroepithelium is maintained by a critical balance between proliferation and cell-cell adhesion of neural progenitor cells. The molecular mechanisms that underlie this are still largely unknown. Here, through analysis of a conditional knockout mouse for the Kap3 gene, we show that post-Golgi ...
transport of N-cadherin by the KIF3 molecular motor complex is crucial for maintaining this balance. N-cadherin and beta-catenin associate with the KIF3 complex by co-immunoprecipitation, and colocalize with KIF3 in cells. Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Animals, Brain, Cadherins, Cell Adhesion, Cell Differentiation, Cell Transformation, Neoplastic, Cells, Cultured, Cytoskeletal Proteins, Golgi Apparatus, Mice, Molecular Motor Proteins, Morphogenesis, Neuroepithelial Cells, Neurons, Trans-Activators, beta Catenin
Nat. Cell Biol.
Date: May. 01, 2005
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