PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.
A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle ... and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).
Mesh Terms:
Allosteric Regulation, Amino Acid Sequence, Animals, Base Sequence, Chickens, Cloning, Molecular, Databases as Topic, Glycogen, Humans, Liver, Macromolecular Substances, Mice, Molecular Sequence Data, Molecular Weight, Muscle, Skeletal, Myocardium, Organ Specificity, Phosphoprotein Phosphatases, Phylogeny, Polymerase Chain Reaction, Protein Phosphatase 1, Rabbits, Rats, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Amino Acid
Allosteric Regulation, Amino Acid Sequence, Animals, Base Sequence, Chickens, Cloning, Molecular, Databases as Topic, Glycogen, Humans, Liver, Macromolecular Substances, Mice, Molecular Sequence Data, Molecular Weight, Muscle, Skeletal, Myocardium, Organ Specificity, Phosphoprotein Phosphatases, Phylogeny, Polymerase Chain Reaction, Protein Phosphatase 1, Rabbits, Rats, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Amino Acid
FEBS Lett.
Date: Nov. 24, 1997
PubMed ID: 9414128
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