The MAK-V protein kinase regulates endocytosis in mouse.
We report the cloning of a mouse cDNA encoding the MAK-V protein kinase, with a putative specificity for serine/threonine residues. The mak-v gene is transcribed in adult brain and in the mouse embryo from at least 7.5 dpc. Using the yeast two-hybrid system, we showed that MAK-V interacts with Rabaptin-5, ... a protein which plays an important role in endocytosis. Functional studies of the MAK-V protein suggest that it regulates endocytosis. We also constructed a human mak-v cDNA and localized the human mak-v gene at 21q22.11. Its chromosomal location suggests that mak-v could be involved in disorders of the nervous system, development or in malignancies.
Mesh Terms:
Amino Acid Sequence, Animals, Brain, Chromosomes, Human, Pair 21, Cloning, Molecular, DNA Primers, DNA, Complementary, Endocytosis, Gene Expression, Humans, Mice, Molecular Sequence Data, Nerve Tissue, Protein Kinases, Protein-Serine-Threonine Kinases, Sequence Homology, Amino Acid, Species Specificity, Two-Hybrid System Techniques
Amino Acid Sequence, Animals, Brain, Chromosomes, Human, Pair 21, Cloning, Molecular, DNA Primers, DNA, Complementary, Endocytosis, Gene Expression, Humans, Mice, Molecular Sequence Data, Nerve Tissue, Protein Kinases, Protein-Serine-Threonine Kinases, Sequence Homology, Amino Acid, Species Specificity, Two-Hybrid System Techniques
Mol. Gen. Genet.
Date: Nov. 01, 2000
PubMed ID: 11129044
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