An activating immunoreceptor complex formed by NKG2D and DAP10.
Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic ... domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors.
Mesh Terms:
1-Phosphatidylinositol 3-Kinase, Amino Acid Sequence, Animals, Binding Sites, Cell Line, Cytotoxicity, Immunologic, Humans, Killer Cells, Natural, Ligands, Lymphocyte Activation, Membrane Proteins, Mice, Molecular Sequence Data, NK Cell Lectin-Like Receptor Subfamily K, Neoplasms, Phosphorylation, Phosphotyrosine, Receptors, Immunologic, Receptors, Natural Killer Cell, Signal Transduction, T-Lymphocytes, Tumor Cells, Cultured, src Homology Domains
1-Phosphatidylinositol 3-Kinase, Amino Acid Sequence, Animals, Binding Sites, Cell Line, Cytotoxicity, Immunologic, Humans, Killer Cells, Natural, Ligands, Lymphocyte Activation, Membrane Proteins, Mice, Molecular Sequence Data, NK Cell Lectin-Like Receptor Subfamily K, Neoplasms, Phosphorylation, Phosphotyrosine, Receptors, Immunologic, Receptors, Natural Killer Cell, Signal Transduction, T-Lymphocytes, Tumor Cells, Cultured, src Homology Domains
Science
Date: Jul. 30, 1999
PubMed ID: 10426994
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