The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.

The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. ...
Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation in cultured myotubes; in particular, the Dok-7 phosphotyrosine-binding domain and its target in MuSK are indispensable. Mice lacking Dok-7 formed neither acetylcholine receptor clusters nor neuromuscular synapses. Thus, Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK.
Mesh Terms:
Agrin, Amino Acid Motifs, Amino Acid Sequence, Animals, Cell Differentiation, Cell Line, Down-Regulation, Enzyme Activation, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Motor Endplate, Muscle Denervation, Muscle Fibers, Skeletal, Muscle Proteins, Muscle, Skeletal, Mutation, Neuromuscular Junction, Phosphorylation, Protein Binding, Protein Structure, Tertiary, Receptor Aggregation, Receptor Protein-Tyrosine Kinases, Receptors, Cholinergic, Synapses, Synaptic Transmission
Science
Date: Jun. 23, 2006
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