Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone ... and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Line, DNA, Gene Expression Regulation, Humans, Ligands, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Oligodeoxyribonucleotides, Protein Binding, Receptors, Retinoic Acid, Receptors, Thyroid Hormone, Recombinant Fusion Proteins, Repressor Proteins, Transcription, Genetic, Transfection, Tretinoin, Triiodothyronine
Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Line, DNA, Gene Expression Regulation, Humans, Ligands, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Oligodeoxyribonucleotides, Protein Binding, Receptors, Retinoic Acid, Receptors, Thyroid Hormone, Recombinant Fusion Proteins, Repressor Proteins, Transcription, Genetic, Transfection, Tretinoin, Triiodothyronine
Nature
Date: Oct. 05, 1995
PubMed ID: 7566114
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