Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons.

We identified a stomatin-related olfactory protein (SRO) that is specifically expressed in olfactory sensory neurons (OSNs). The mouse sro gene encodes a polypeptide of 287 amino acids with a calculated molecular weight of 32 kDa. SRO shares 82% sequence similarity with the murine stomatin, 78% with Caenorhabditis elegans MEC-2, and ...
77% with C. elegans UNC-1. Unlike other stomatin-family genes, the sro transcript was present only in OSNs of the main olfactory epithelium. No sro expression was seen in vomeronasal neurons. SRO was abundant in most apical dendrites of OSNs, including olfactory cilia. Immunoprecipitation revealed that SRO associates with adenylyl cyclase type III and caveolin-1 in the low-density membrane fraction of olfactory cilia. Furthermore, anti-SRO antibodies stimulated cAMP production in fractionated cilia membrane. SRO may play a crucial role in modulating odorant signals in the lipid rafts of olfactory cilia.
Mesh Terms:
Adenylate Cyclase, Animals, Antibodies, Blood Proteins, Caveolin 1, Caveolins, Cell Line, Cell Membrane, Cilia, Dendrites, Humans, In Situ Hybridization, Isoenzymes, Kidney, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Olfactory Mucosa, Olfactory Receptor Neurons, Precipitin Tests, Recombinant Fusion Proteins, Sequence Homology, Amino Acid, Signal Transduction, Subcellular Fractions, Transfection, Vomeronasal Organ
J. Neurosci.
Date: Jul. 15, 2002
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