Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.
The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This ... recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin.
Mesh Terms:
Active Transport, Cell Nucleus, Animals, Cytosol, HSP90 Heat-Shock Proteins, Hepatocytes, Liver, Mice, Mice, Inbred Strains, Phenobarbital, Phosphoprotein Phosphatases, Protein Phosphatase 2, Protein Transport, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Transcriptional Activation
Active Transport, Cell Nucleus, Animals, Cytosol, HSP90 Heat-Shock Proteins, Hepatocytes, Liver, Mice, Mice, Inbred Strains, Phenobarbital, Phosphoprotein Phosphatases, Protein Phosphatase 2, Protein Transport, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Transcriptional Activation
FEBS Lett.
Date: Jul. 31, 2003
PubMed ID: 12885400
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