delta-Protocadherins: a gene family expressed differentially in the mouse brain.

Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members ...
of the delta1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1alpha. Like most classic cadherins, each of three delta1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta1-protocadherins. Together, these results suggest that the members of the delta1-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.
Mesh Terms:
Amino Acid Sequence, Animals, Brain, Cadherins, Cloning, Molecular, Gene Expression, Gene Library, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Multigene Family, Phylogeny, Sequence Alignment
Cell. Mol. Life Sci.
Date: Jun. 01, 2005
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