The tripartite motif family identifies cell compartments.
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they ... identify specific cell compartments.
Mesh Terms:
Amino Acid Motifs, Animals, Blotting, Northern, Carrier Proteins, Cell Compartmentation, Cell Line, Chromosome Mapping, Cloning, Molecular, Databases, Factual, Embryo, Mammalian, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Multigene Family, Mutagenesis, Site-Directed, Nerve Tissue Proteins, Organ Specificity, Protein Binding, Protein Structure, Tertiary, Proteins, Sequence Homology, Amino Acid, Subcellular Fractions, Two-Hybrid System Techniques
Amino Acid Motifs, Animals, Blotting, Northern, Carrier Proteins, Cell Compartmentation, Cell Line, Chromosome Mapping, Cloning, Molecular, Databases, Factual, Embryo, Mammalian, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Multigene Family, Mutagenesis, Site-Directed, Nerve Tissue Proteins, Organ Specificity, Protein Binding, Protein Structure, Tertiary, Proteins, Sequence Homology, Amino Acid, Subcellular Fractions, Two-Hybrid System Techniques
EMBO J.
Date: May. 01, 2001
PubMed ID: 11331580
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