The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.
The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased ... in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.
Mesh Terms:
Animals, Blotting, Western, Cell Line, Endosomal Sorting Complexes Required for Transport, Hela Cells, Humans, Immunoprecipitation, Male, Muscles, Protein Binding, Protein Structure, Tertiary, Protein Tyrosine Phosphatases, Non-Receptor, Rats, Ubiquitin-Protein Ligases, Ubiquitination
Animals, Blotting, Western, Cell Line, Endosomal Sorting Complexes Required for Transport, Hela Cells, Humans, Immunoprecipitation, Male, Muscles, Protein Binding, Protein Structure, Tertiary, Protein Tyrosine Phosphatases, Non-Receptor, Rats, Ubiquitin-Protein Ligases, Ubiquitination
Biochem. J.
Date: Apr. 01, 2009
PubMed ID: 19125695
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- Interactions 3
- PTM Genes 1