NEMO stabilizes c-Myc through direct interaction in the nucleus.
The transcription factor c-Myc is a cellular oncoprotein generally upregulated in most of human cancers. NF-κB essential modulator (NEMO) caused phosphorylation and stabilization of c-Myc protein in the nucleus through direct interaction. The interaction caused reduced ubiquitination of c-Myc by inhibiting ubiquitinating activity of Fbw7 without blocking the interaction between ... c-Myc and Fbw7. As a consequence, NEMO enhanced the expression of several selected c-Myc targets. Compared to the classical role as an essential subunit for the activity of IKK complex, stabilization of c-Myc by direct interaction is a unique function of NEMO, representing a new mechanism to regulate c-Myc activity.
Mesh Terms:
Cell Line, Tumor, Cell Nucleus, Humans, Intracellular Signaling Peptides and Proteins, Phosphorylation, Protein Binding, Protein Stability, Proto-Oncogene Proteins c-myc, Up-Regulation
Cell Line, Tumor, Cell Nucleus, Humans, Intracellular Signaling Peptides and Proteins, Phosphorylation, Protein Binding, Protein Stability, Proto-Oncogene Proteins c-myc, Up-Regulation
FEBS Lett.
Date: Nov. 19, 2010
PubMed ID: 20970423
View in: Pubmed Google Scholar
Download Curated Data For This Publication
126232
Switch View:
- Interactions 2
- PTM Genes 1