Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.

Ufd2 is a U-box containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of APC E3, requires Ufd2 enzyme. Yeast cells lacking UFD2 exhibit ...
altered chromosome stability and several spindle related phenotypes, expanding the biological function of Ufd2. We demonstrated that Ufd2-mediated Mps1 degradation is conserved in human. Our results underscore the significance of Ufd2 in proteolysis and further suggest that Ufd2-like enzymes regulate far more substrates than previously envisioned.
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Date: Nov. 01, 2011
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