CDK11p58 represses vitamin D receptor-mediated transcriptional activation through promoting its ubiquitin-proteasome degradation.

Vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and regulates transcription of target genes. In this study, we identified CDK11(p58) as a novel protein involved in the regulation of VDR. CDK11(p58), a member of the large family of p34cdc2-related kinases, is associated with cell cycle progression, ...
tumorigenesis, and apoptotic signaling. Our study demonstrated that CDK11(p58) interacted with VDR and repressed VDR-dependent transcriptional activation. Furthermore, overexpression of CDK11(p58) decreased the stability of VDR through promoting its ubiquitin-proteasome-mediated degradation. Taken together, these results suggest that CDK11(p58) is involved in the negative regulation of VDR.
Mesh Terms:
Animals, COS Cells, Cercopithecus aethiops, Cyclin D3, Cyclins, Humans, Proteasome Endopeptidase Complex, Receptors, Calcitriol, Transcriptional Activation, Transfection, Ubiquitin, Ubiquitination
Biochem. Biophys. Res. Commun.
Date: Aug. 28, 2009
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