Sumoylation of Drosophila transcription factor STAT92E.
STAT92E is an essential transcription factor in Drosophila melanogaster for the development of several organs and the immune system. The JAK/STAT pathway employs different evolutionary conserved regulatory mechanisms to control biological processes. Numerous transcription factors in both mammals and invertebrates have been shown to be either activated or inhibited by ... a covalent modification with a small ubiquitin-like modifier (Sumo). Here, we show that Drosophila STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells. Mutation of Lys187 increases the transcriptional activity of STAT92E, thus suggesting that sumoylation of STAT92E has a repressive role in the regulation of the JAK/STAT pathway in Drosophila melanogaster.
Mesh Terms:
Animals, COS Cells, Cercopithecus aethiops, Drosophila Proteins, Drosophila melanogaster, Gene Expression Regulation, Developmental, Hematopoiesis, Humans, Mutation, Organogenesis, RNA, Small Interfering, Repressor Proteins, STAT Transcription Factors, SUMO-1 Protein, Signal Transduction, Sumoylation
Animals, COS Cells, Cercopithecus aethiops, Drosophila Proteins, Drosophila melanogaster, Gene Expression Regulation, Developmental, Hematopoiesis, Humans, Mutation, Organogenesis, RNA, Small Interfering, Repressor Proteins, STAT Transcription Factors, SUMO-1 Protein, Signal Transduction, Sumoylation
J Innate Immun
Date: Jul. 10, 2010
PubMed ID: 20616536
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