Homo sapiens
PCSK9
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PSEC0052
proprotein convertase subtilisin/kexin type 9
GO Process (17)
GO Function (11)
GO Component (11)
Gene Ontology Biological Process
- cellular response to insulin stimulus [ISS]
- cellular response to starvation [ISS]
- cholesterol homeostasis [IMP]
- kidney development [ISS]
- liver development [ISS]
- low-density lipoprotein particle receptor catabolic process [IDA]
- lysosomal transport [IDA]
- negative regulation of low-density lipoprotein particle clearance [IDA]
- negative regulation of receptor recycling [IDA]
- neurogenesis [ISS]
- neuron differentiation [ISS]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of receptor internalization [IDA]
- protein autoprocessing [IDA]
- proteolysis [IBA]
- regulation of neuron apoptotic process [ISS]
- regulation of receptor activity [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
129116
9606
Switch View:
- Interactors 139
- Interactions 147
- Chemical Interactions 1
- Network
- PTM Sites 4