KIAA0202, a human septin family member, interacting with hPFTAIRE1.
hPFTAIRE1 is a member of Cdc2-related kinase family localized in cytoplasm. To search its substrates and regulatory proteins, the hPFTAIRE1 was fused to LexA and used as bait to screen a human brain LexA two-hybrid library. In this screening, 7 hPFTAIRE1 interacting proteins, including KIAA0202, were obtained. The interaction between ... the KIAA0202 and the hPFTAIRE1 was confirmed by using immunoprecipitation. The KIAA0202 is a 508 aa protein and is a member of septin family. The central portion of the KIAA0202 is a GTP-CDC domain, which is conserved among almost all septins. Its C-terminus is a coiled-coil structure and its N-terminus is a variable region. Our results suggest that the KIAA0202 may play important roles in functional regulation of hPFTAIRE1.
Mesh Terms:
Amino Acid Sequence, Brain, GTP Phosphohydrolases, Humans, Membrane Proteins, Molecular Sequence Data, Precipitin Tests, Protein Binding, Protein Kinases, Sequence Homology, Amino Acid, Two-Hybrid System Techniques
Amino Acid Sequence, Brain, GTP Phosphohydrolases, Humans, Membrane Proteins, Molecular Sequence Data, Precipitin Tests, Protein Binding, Protein Kinases, Sequence Homology, Amino Acid, Two-Hybrid System Techniques
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao
Date: Jul. 01, 2002
PubMed ID: 12098780
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