CtBPs promote mitotic fidelity through their activities in the cell nucleus.

CtBPs form NADH-sensitive chromatin-modifying complexes, which link cellular metabolism to gene transcription. They also function in the cytoplasm to regulate Golgi fissioning; their inhibition can consequently cause a Golgi-dependent checkpoint in G(2). We have recently identified a novel role of CtBPs in the maintenance of mitotic fidelity; inhibition of CtBP ...
synthesis resulting in reduced association of aurora B with mitotic chromatin and aberrant segregation of chromosomes. Here, we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity.
Mesh Terms:
Alcohol Oxidoreductases, Breast Neoplasms, Cell Line, Tumor, Cell Nucleus, DNA-Binding Proteins, Female, Humans, Mitosis, Nerve Tissue Proteins
Oncogene
Date: Mar. 17, 2011
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