[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].

Humanine is a human neuroprotective peptide with a wide action spectrum. To analyze molecular mechanisms of humanin functioning, a search for proteins interacting with this peptide was conducted using yeast two-hybrid system. Screening of human fetal brain cDNA library identified seven proteins with different functions that specifically interacted with humanin.
Mesh Terms:
Cloning, Molecular, Humans, Intracellular Signaling Peptides and Proteins, Neuropeptides, Neuroprotective Agents, Protein Binding, Two-Hybrid System Techniques
Genetika
Date: Feb. 01, 2006
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