A bipartite late-budding domain in human immunodeficiency virus type 1.

Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans-complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 sequences to mediate the formation of ...
infectious extracellular HIV-1 virions. These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6.
Mesh Terms:
Amino Acid Motifs, Gene Products, gag, HIV-1, Ubiquitin, Virion
J. Virol.
Date: Nov. 01, 2003
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