Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.
p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 ... has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial for Tip60-dependent p53 acetylation at Lys120, therefore facilitating activation of the proapoptotic targets. These studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.
Mesh Terms:
Acetylation, Amino Acid Sequence, Apoptosis, Base Sequence, Blotting, Western, Carrier Proteins, Cell Cycle Checkpoints, Cell Line, DNA Damage, Histone Acetyltransferases, Humans, Immunoprecipitation, Molecular Sequence Data, Multiprotein Complexes, Oligonucleotides, RNA Interference, Sequence Analysis, DNA, Tumor Suppressor Protein p53
Acetylation, Amino Acid Sequence, Apoptosis, Base Sequence, Blotting, Western, Carrier Proteins, Cell Cycle Checkpoints, Cell Line, DNA Damage, Histone Acetyltransferases, Humans, Immunoprecipitation, Molecular Sequence Data, Multiprotein Complexes, Oligonucleotides, RNA Interference, Sequence Analysis, DNA, Tumor Suppressor Protein p53
Proc. Natl. Acad. Sci. U.S.A.
Date: Nov. 22, 2011
PubMed ID: 22084066
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