Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster.
The thoracic integument of the adult fruit fly is a relatively simple but highly patterned structure. It is composed of sensory organ cells distributed within a monolayer of epidermal cells. Both cell types are easily detected at the cuticular surface, as each external sense organ forms a sensory bristle and ... each epidermal cell secretes a small nonsensory hair. Inhibitory cell-cell interactions play a key role in regulating the distribution as well as the formation of the sense organs. This review focuses on the role of these cell-cell interactions in the adoption of alternative cell fates. We also show that Notch, Hairless, and Suppressor of Hairless, three components of this intercellular signaling pathway, exhibit dose-dependent genetic interactions. Finally we address how this intercellular signaling mechanism may be modulated to result in highly reproducible outcomes.
Mesh Terms:
Animals, Cell Communication, Crosses, Genetic, Drosophila Proteins, Drosophila melanogaster, Female, Gene Expression, Genes, Insect, Hot Temperature, Male, Mechanoreceptors, Membrane Proteins, Models, Biological, Nervous System, Nervous System Physiological Phenomena, Neurons, Protein Biosynthesis, Pupa, Receptors, Notch, Signal Transduction, Transcription Factors
Animals, Cell Communication, Crosses, Genetic, Drosophila Proteins, Drosophila melanogaster, Female, Gene Expression, Genes, Insect, Hot Temperature, Male, Mechanoreceptors, Membrane Proteins, Models, Biological, Nervous System, Nervous System Physiological Phenomena, Neurons, Protein Biosynthesis, Pupa, Receptors, Notch, Signal Transduction, Transcription Factors
Dev. Genet.
Date: Jan. 01, 1996
PubMed ID: 8742832
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